In this interview, return guest Stephanie Seneff, Ph.D., a senior research scientist at MIT for over five decades,1 discusses her paper,2
“Innate Immune Suppression by SARS-CoV-2 mRNA Vaccinations: The Role of
G-quadruplexes, Exosomes and MicroRNAs,” published in the June 2022
issue of Food and Chemical Toxicology.
The paper was co-written with Drs. Peter McCullough, Greg Nigh and
Anthony Kyriakopoulos. In May 2021, Nigh and Seneff published a paper3 detailing the differences between the spike protein and the COVID jab spike protein.
In the “Innate Immune Suppression” paper, they and their other
co-authors delve deep into the mechanisms of the COVID shots, showing
how they suppress your innate immune system.
The paper caused quite a stir when it was first posted, prior to
publication. A campaign was launched to have it retracted on the premise
that it would discourage people from getting these life-saving shots —
regardless of whether the mechanisms described were true or not.
Ultimately, the controversy led to the resignation of the editor of
the journal. Many have also tried to discredit Seneff, and McCullough
has since been stripped of his medical credentials.4
Understanding G-Quadruplexes
G-quadruplexes (G4) are genomewide targets of transcriptional
regulation, and as such as a novel target for drug design. The “G” in G4
stands for guanine, so G4 is DNA sequence of four guanines. It’s one of
the four nucleotides — the basic code — in DNA, and it’s known to play
an important role in diseases such as cancers and neurological
disorders.5
As explained by Seneff, prions, when
misfolded, build beta sheets and precipitate out of the cytoplasm,
causing plaque to form. This plaque is a hallmark of several
neurodegenerative diseases in animals and humans, such as Mad Cow
disease, Creutzfeldt-Jakob disease, scrapie (which affects sheep) and
chronic wasting disease in deer.
“So, there are all these debilitating
neurodegenerative diseases that come out of the prion protein, and the
prion protein actually binds to its own G4s, which are in its own RNA,” Seneff explains. “In so doing, it promotes [the prion protein] to misfold into the wrong shape ... [which] causes prion disease.
The [COVID jabs] produce a version of the messenger
RNA (mRNA) that codes for the spike protein. Their version is enriched
in guanines — it produces a lot more G4s than the original mRNA that the
virus produces — so, it's a different form.
And there's lots of mRNA in the [COVID jab]. It's a
big dose of this mRNA that is enriched in G4s ... which then ... causes
the cell to produce the prion protein. So, the cell is producing the
prion protein in the context of a situation with lots of G4s lying
around from the mRNA from vaccine. That's a really dangerous situation
for causing the prion protein to misfold and causing prion disease.”
How the COVID Jab Can Induce Autoimmune Disease
As explained by Seneff, the mRNA in the jab is taken into your lymph
system and spleen, germinal centers where antibodies are produced, and
in order to produce the antibodies, these germinal centers release
exosomes. This can help explain the phenomenon of “shedding,” but it
also helps explain the immune destruction we see occurring. Seneff
explains:
“The exosomes are part of the process by which the
cells communicate to induce the antibody production, which is the goal
of the [COVID jab]. The [jab] does a fantastic job of producing high
levels of IgG [immunoglobulin] antibodies, which are the ones that are
associated with autoimmune disease.
It doesn't make the mucosal antibodies. It makes IgG,
which is actually much more dangerous if there are too many antibodies.
They can cause autoimmune disease through molecular mimicry, and that's
another aspect that I think is going on.
That's why you're getting this platelet problem where
platelet count goes down to zero, because you get antibodies to the
platelets by molecular mimicry, or even because the spike protein is
binding to the platelets. They're getting antibodies to the complex and
you're wiping out the platelets.
Some people are getting thrombocytopenia and VITT
[vaccine-induced immune thrombotic thrombocytopenia], conditions that
can be life-threatening. And there's a huge signal for thrombosis. The
paper talks about thrombosis. We have ... seven tables for different
aspects of the symptoms of the vaccine.
There's a table on the liver, there's a table on
thrombosis, there's a table on cancer, there's a table on the vagus
nerve, and all of the inflammations of the nerves because those exosomes
are traveling up the vagus nerve, making their way to the heart, brain
and liver.
They're causing disease in all of those organs, and
you see that very clearly in the various databases — 98%, 99% of the
[adverse event] reports in 2021 for these conditions were [from the]
COVID shots and 1% was all the other vaccines combined.”
Mechanism of Action
Swiss researchers recently reported finding elevated troponin levels
in 100% of COVID jabbed individuals, indicating everyone is suffering
some degree of heart damage, even if they’re asymptomatic.6,7 Seneff explains the mechanism by which the COVID shot damages your heart.
“I think the whole issue is the spike protein being
released by the immune cells in the germinal centers — the lymph system
and the spleen releasing these exosomes that then travel along their
fibers and reach all these critical organs.
The spleen has a very good connectivity with the
liver, heart, brain and gut via the nerve system, starting with the
splanchnic nerve and then hooking up to the vagus nerve ... So, these
exosomes are migrating along the vagus nerve and they're arriving at
these organs and are getting taken up by cells there. And everywhere
they go, they cause inflammation.
The spike protein is very good at causing
inflammation. That's been shown in multiple studies ... It causes the
immune cells to migrate to the heart, and that's how you get
myocarditis, this inflammation in the heart.
You also get inflammation in the muscles. I was
looking at myositis, which is muscle inflammation, and that's another
issue. I've been in contact with multiple people who suffered severe
muscle damage from the spike protein, even to the point of being
debilitated because of [inflammation in the] muscles.
So, not just the heart, but the skeletal muscles are
also affected in a really bad way. Inflammation in the brain also causes
neurons to be damaged and that's causing cognitive disorders.
So, I think the long COVID is caused by the spike
protein reaching the brain. Many papers have talked about long COVID,
and they think it's the spike protein, not the virus, but the spike
protein itself [that is causing it].”
The Role of MicroRNAs
Another piece of the puzzle is related to the role of microRNAs,
which are embedded in the exosomes that travel to the tissues. MicroRNAs
should not be confused with mRNA. They’re two different things. The
microRNAs are short pieces of RNA, about 22 nucleotides long. Unlike
mRNA, microRNA do not code for protein.
The mRNA in the jabs are designed to be extremely resilient.
Normally, mRNA lasts a few hours, but the mRNA in the jabs stick around
producing protein in cells for several months, at minimum primarily
because of the substitution of the nucleotide uridine with
pseudouridine.
Because the mRNA is so resilient, spleen cells have to try to cope
with all the spike protein that they cannot stop making, and one way
they do that is by pushing the spike protein out in the form of
exosomes. Those exosomes also contain microRNAs. Indian researchers
found two specific microRNAs in people who got the jab, and these
microRNAs interfere with Type 1 interferon response.
“This is a big topic of our paper,” Seneff says. “We talk about innate immune suppression ... due to the effect of these microRNAs that are packaged up with the spike protein.
Everywhere [the exosomes] go, they deliver these
microRNAs, which disrupt the immune cell's ability to respond to Type 1
interferon. These microRNAs actually have a very high-level controlling
role in the regulatory process of biology. They control which genes are
expressed.”
Hypothesis to Explain Post-Jab Sudden Death
Seneff goes on to cite animal research from 2005, in which mice were
exposed to a virus that causes myocarditis. They wanted to see what
would happen if the mice were suffering from myocarditis and then got a
shot of adrenaline. So, the mice were infected with the
myocarditis-inducing virus, and then, 120 days later, they injected them
with adrenaline.
The dose given killed 70% of them. Meanwhile, control mice that did
not have myocarditis suffered no ill effect when injected with the same
dose of adrenaline. The mice that died, died of heart failure.
Basically, their hearts were too damaged to withstand the adrenaline
rush. Today, we’re seeing a similar effect in athletes, who are dropping
dead while exerting themselves.
Digging for other papers, Seneff found one that detailed the Type 1
interferon response in chromaffin cells, the cells that make adrenaline.
Type 1 interferon inhibits and reduces their production of adrenaline.
Seneff’s theory is that the COVID jabs interferes with your body’s
ability to respond to Type 1 interferon, thereby allowing too much
adrenaline to be released. If your heart has been damaged by the spike
protein, the outcome could be lethal, as we’ve seen.
“I think that could be what's going on with the
sudden death problem, because we certainly are seeing lots of young
people suddenly dying of heart issues,” she says.
At the same time, microthrombi (micro blood clots) are activated by
the spike protein, which could have lethal effects, and endothelial
cells (the cells lining your blood vessels) are also inflamed. So,
there’s not just one mechanism by which the jabs could kill you.
Spike Protein Creates Incredibly Tough Blood Clots
According to Seneff, blood clots are also connected to the prion
aspect. Many different proteins are amyloidogenic and can misfold,
causing them to precipitate out, including proteins in your blood. Blood
clots are tough to break down, and when you add spike protein into
them, they become even tougher.
Seneff suspects the spike protein binds to fibrin, causing it then to
misfold in a way that makes it very resistant to breaking down. The
same thing happens with prion proteins. When they misfold, they create a
gel that becomes denser over time, eventually becoming completely
inaccessible to the water base.
“It just precipitates out as this thing that just sits there for the rest of your life,” Seneff says. “Nothing can get at it. The immune cells can't break it down. It just stays there. It can't be cleared.”
This is why I recommend taking fibrinolytic enzymes like lumbrokinase
(which is the most effective), serrapeptase and nattokinase, several
times a day one hour before or two hours after a meal, if you’re
struggling with long COVID, as they help break down the fibrin. To work,
you have to take them between meals, on an empty stomach, or else
they’ll just act as a digestive enzyme to break down food.
Another technique is to use a near-infrared sauna, which will help address the misfolding of proteins by encouraging autophagy, your body’s natural clean-out process.
The Role of Antibodies in Prion Disease
Antibodies may also play a role in the devastating side effects from
the COVID jab. We know that prion protein is upregulated in cells that
produce it under stress, and the COVID jab spike protein has been shown
to cause cells to make more prion protein. One possibility is that
antibodies to a particular part of the spike protein end up binding to
the prion protein through molecular mimicry.
As explained by Seneff, researchers have discovered that if you
produce antibodies to the C-terminal end of the prion protein, it can
cause disease that looks a lot like prion disease but develops much
faster.
As it turns out, the antibodies to the C-terminal end of the prion
protein prevent the prion protein from going into the endoplasmic
reticulum (ER), where it needs to go in order to do its job. Instead,
the antibodies keep the prion in the cytoplasm.
Subsequently, the cell gets sick because of these antibodies. The
late Luc Montagnier posted a case study with 26 people who developed
symptoms of prion disease within the first month after their second
vaccine. All died, many within three months of their diagnosis. All were
dead within a year, from what was basically an extremely aggressive
form of Creutzfeldt-Jakob disease (the human Mad Cow disease
equivalent).
Seneff believes antibodies against the spike protein are to blame,
because it didn’t happen until they got their second dose. Antibodies
developed after that first dose, which primed the cells. Then, after the
second dose the cells started making loads of spike protein again,
which the antibodies bound to.
This exosome package then traveled up the vagus nerve to the brain,
where neurons took them up. Seneff suspects this explains the disease
process on those 26 patients.
“It would be explained completely by this model of
spike protein antibodies binding to the C-terminal domain and preventing
the prion protein from going into the ER,” she says, “and then, it causes [the prion protein] to break down.
It gets broken down by the proteasome and disappears.
So, it's causing a loss of function problem for the prion protein in
the neuron at a very accelerated rate, much faster than what goes on
with the normal prion disease ...
Montagnier and his team identified a segment of the
spike protein that they thought had characteristic prion-like features.
Within that segment is a piece that has five amino acids, YQRGS.
The prion protein has [the same] piece ... Except for
the middle one, the other four [amino acids] are all identical with
this piece near the C-terminal end of the prion protein. So, it's really
perfect. It's a place where, if you get antibodies to that, it’s
basically a death sentence.”
COVID Jabs Impair Your Immune Function
To circle back to where we began, it seems the reason so many jabbed
individuals are now contracting COVID and other infections, and are
dying from them, is because Type 1 interferon is suppressed. That
suppresses your immune function, making you more prone to contracting
infections.
In the interview, Seneff also reviews how chronic exposure to
glyphosate is a predisposing condition for bad COVID-19 outcomes, as
glyphosate disrupts the immune system. For more details on that, please
listen to the interview in its entirety. We also review how glycine
supplementation can help displace glyphosate in your body, thereby
limiting its damaging influence.
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